New Urine Test May Help Some Men with Elevated PSA Avoid Biopsy.





Prostate cancer is one of the most common cancers among men, and early detection is crucial for effective treatment. Traditionally, men with elevated prostate-specific antigen (PSA) levels have faced the prospect of a biopsy to determine if cancer is present. However, a new urine test offers a promising alternative that may help some men avoid this invasive procedure. In this blog post, we’ll explore the significance of this new test, how it works, and its potential benefits for men with elevated PSA levels.

Understanding PSA and Its Role in Prostate Cancer Detection

PSA is a protein produced by both normal and malignant cells in the prostate gland. Elevated levels of PSA in the blood can indicate the presence of prostate cancer, but they can also be caused by other conditions such as benign prostatic hyperplasia (BPH) or prostatitis. Consequently, an elevated PSA level often leads to a prostate biopsy to determine the cause.

The New Urine Test: An Overview

The new urine test, known as the SelectMDx test, is designed to identify men at higher risk of prostate cancer who would benefit most from a biopsy. It measures the expression of specific genes associated with prostate cancer in a urine sample collected after a digital rectal exam (DRE). These genes include HOXC6 and DLX1, which are linked to the presence of prostate cancer and its aggressiveness.

How the SelectMDx Test Works

  1. Sample Collection: The test requires a urine sample collected immediately after a DRE, which helps to release prostate cells into the urine.
  2. Gene Expression Analysis: The urine sample is analyzed for the expression levels of the HOXC6 and DLX1 genes.
  3. Risk Assessment: The results are used to calculate a risk score that indicates the likelihood of clinically significant prostate cancer.

Benefits of the New Urine Test

  1. Reduced Need for Biopsies: The test helps identify men who are less likely to have aggressive prostate cancer, potentially sparing them from unnecessary biopsies.
  2. Non-Invasive: Unlike a biopsy, which involves removing tissue from the prostate, the urine test is non-invasive and poses no risk of complications such as infection or bleeding.
  3. Early Detection of Aggressive Cancer: By focusing on genes associated with aggressive cancer, the test can help prioritize biopsies for those most at risk, facilitating early detection and treatment.
  4. Cost-Effective: Reducing the number of unnecessary biopsies can lead to cost savings for both patients and healthcare systems.

Who Should Consider the SelectMDx Test?

The SelectMDx test is particularly beneficial for men with elevated PSA levels who are considering a biopsy. It is also useful for those with a family history of prostate cancer or other risk factors who want to make informed decisions about their health care.


The new urine test for prostate cancer risk assessment represents a significant advancement in the early detection and management of the disease. By reducing the need for unnecessary biopsies and focusing on the identification of aggressive cancer, this test offers a more precise and patient-friendly approach to prostate cancer screening. Men with elevated PSA levels should discuss the potential benefits of the SelectMDx test with their healthcare providers to determine if it is a suitable option for them.

For more information on prostate cancer screening and the latest advancements, visit the American Cancer Society.

By incorporating this new urine test into prostate cancer screening protocols, we can improve early detection and treatment outcomes while minimizing unnecessary invasive procedures.


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